World Library  
Flag as Inappropriate
Email this Article

Methylmethaqualone

Article Id: WHEBN0010387804
Reproduction Date:

Title: Methylmethaqualone  
Author: World Heritage Encyclopedia
Language: English
Subject: Mebroqualone, Etaqualone, Mecloqualone, Diproqualone, Cloroqualone
Collection: Convulsants, Designer Drugs, Gabaa Receptor Positive Allosteric Modulators, Quinazolinones, Sedatives
Publisher: World Heritage Encyclopedia
Publication
Date:
 

Methylmethaqualone

Methylmethaqualone
Systematic (IUPAC) name
3-(2,4-dimethylphenyl)-2-methylquinazolin-4(3H)-one
Clinical data
Legal status
?
Identifiers
CAS number  YesY
ATC code None
PubChem
ChemSpider  YesY
Chemical data
Formula C17H16N2O 
Mol. mass 264.322
 YesY   

Methylmethaqualone (MMQ) is a quinazolinone and an analogue of methaqualone that has similar sedative and hypnotic properties to its parent compound (resulting from its agonist activity at the β subtype of the GABAA receptor), and is around the same potency. Methylmethaqualone differs from methaqualone by 4-methylation on the phenyl ring. It was made illegal in Germany in 1999 and listed by the DEA as a "drug of forensic interest" at about the same time, but little other information is available. It would appear that this compound was sold on the black market in Germany as a designer drug analogue of methaqualone.[1][2]

Animal studies of methylmethaqualone have shown it to produce convulsions at only slightly above the effective sedative dose,[3] and anecdotal reports from human users have confirmed that it can have a pro-convulsive effect, which has potential to make this compound particularly hazardous if taken in excessive doses. One user reported no effect at 2000mg.

References

  1. ^ Klein RFX, Hays PA (January–June 2003;). "Detection and Analysis of Drugs of Forensic Interest, 1992 - 2001; A Literature Review." (pdf). Microgram Journal (DEA) 1 (1–2): 60. 
  2. ^ Angelos, S. A.; Lankin, D. C.; Meyers, J. A.; Raney, J. K. (1993). "The Structural Identification of a Methyl Analog of Methaqualone via 2-Dimensional NMR Techniques". Journal of Forensic Sciences 38 (2): 455–465.  
  3. ^ Boltze, K. H.; Dell, H. D.; Lehwald, H.; Lorenz, D.; Rueberg-Schweer, M. (1963). "Substituted 4-Quinazolinone Derivatives As Hypnotics and Anticonvulsants". Arzneimittel-Forschung 13: 688–701.  


This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and USA.gov, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for USA.gov and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
 
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
 
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.
 



Copyright © World Library Foundation. All rights reserved. eBooks from World eBook Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.