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Nkx6-1

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Title: Nkx6-1  
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Nkx6-1

NK6 homeobox 1
Identifiers
Symbols  ; NKX6.1; NKX6A
External IDs GeneCards:
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Homeobox protein Nkx-6.1 is a protein that in humans is encoded by the NKX6-1 gene.[1][2]

Function

In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target genes.[2]

References

  1. ^ Inoue H, Rudnick A, German MS, Veile R, Donis-Keller H, Permutt MA (March 1997). "Isolation, characterization, and chromosomal mapping of the human Nkx6.1 gene (NKX6A), a new pancreatic islet homeobox gene". Genomics 40 (2): 367–70.  
  2. ^ a b "Entrez Gene: NK6 homeobox 1". 

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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