World Library  
Flag as Inappropriate
Email this Article

Ns-2664

Article Id: WHEBN0018767130
Reproduction Date:

Title: Ns-2664  
Author: World Heritage Encyclopedia
Language: English
Subject: NS-2710, Nonbenzodiazepine, Anxiolytics, CP-615,003, Heptobarbital
Collection: Anxiolytics, Benzimidazoles, Furans, Gabaa Receptor Positive Allosteric Modulators, Imidazoles
Publisher: World Heritage Encyclopedia
Publication
Date:
 

Ns-2664

NS-2664
Systematic (IUPAC) name
5-furan-3-yl-1-(3-imidazol-1-yl-phenyl)-1H-benzoimidazole
Clinical data
Legal status
?
Identifiers
ATC code ?
PubChem
ChemSpider  N
Chemical data
Formula C20H14N4O 
Mol. mass 326.351 g/mol
 N   

NS-2664 (LS-193,048) is an anxiolytic drug with a novel chemical structure, developed by the small pharmaceutical company Neurosearch. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic. NS-2664 is a potent but non-selective partial agonist at GABAA receptors, although with little efficacy at the α1 subtype and more at α2 and α3. It has potent anticonvulsant effects in animal studies, but a relatively short duration of action, and produces little sedative effects or physical dependence.[1]

References

  1. ^ Mirza NR, Nielsen EØ. Do subtype-selective gamma-aminobutyric acid A receptor modulators have a reduced propensity to induce physical dependence in mice? Journal of Pharmacology and Experimental Therapeutics. 2006 Mar;316(3):1378-85. PMID 16352707



This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and USA.gov, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for USA.gov and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
 
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
 
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.
 



Copyright © World Library Foundation. All rights reserved. eBooks from World eBook Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.