World Library  
Flag as Inappropriate
Email this Article

Naldemedine

Article Id: WHEBN0035796613
Reproduction Date:

Title: Naldemedine  
Author: World Heritage Encyclopedia
Language: English
Subject: List of opioids, Kobret, 6β-Naltrexol-d4, Hemorphin, Naloxonazine
Collection:
Publisher: World Heritage Encyclopedia
Publication
Date:
 

Naldemedine

Naldemedine
Systematic (IUPAC) name
17-(cyclopropylmethyl)-6,7-didehydro-4,5α-epoxy-3,6,14-trihydroxy-N-[2-(3-phenyl-1,2,4-oxadiazol-5-yl)propan-2-yl]morphinan-7-carboxamide
Clinical data
Legal status
Routes Oral
Identifiers
CAS number
1345728-04-2 (tosylate)
ATC code None
PubChem
Chemical data
Formula C32H34N4O6 
Mol. mass 570.63556 g/mol

Naldemedine (INN, USAN; S-297,995) is a peripherally-selective μ-opioid receptor antagonist under development by Shionogi for the treatment of opioid-induced adverse effects including constipation, nausea, and vomiting.[1][2][3] Clinical studies have thus far found it to possess statistically significant effectiveness for these indications and to be generally well-tolerated with predominantly mild to moderate gastrointestinal side effects.[2] No effects indicative of central opioid withdrawal or impact on the analgesic or mydriatic effects of co-administered opioids have been observed.[1] As of July 2014, naldemedine is in phase III clinical trials in the United States and Japan.

See also

References

  1. ^ a b De Sarro, Giovambattista; Kelly S. Sprawls; Egilius L.H. Spierings; Dustin Tran (2012-03-07). "Drugs in Development for Opioid-Induced Constipation". In Catto-Smith G., Anthony. Constipation - Causes, Diagnosis and Treatment. p. 7.  
  2. ^ a b Shionogi (2009-03-27). "Research and Development at Shionogi (as of March 2009)" (PDF). Retrieved 2012-05-12. 
  3. ^ Nagase H, Fujii H (2011). "Opioids in preclinical and clinical trials". Topics in Current Chemistry 299: 29–62.  



This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and USA.gov, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for USA.gov and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
 
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
 
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.
 



Copyright © World Library Foundation. All rights reserved. eBooks from World eBook Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.