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Nialamide

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Title: Nialamide  
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Language: English
Subject: Mebanazine, Metfendrazine, Safrazine, Octamoxin, Phenoxypropazine
Collection: Amides, Hydrazides, Monoamine Oxidase Inhibitors, Pyridines, Withdrawn Drugs
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Nialamide

Nialamide
Systematic (IUPAC) name
N-benzyl-3-(N'-(pyridine-4-carbonyl)hydrazino)propanamide
Clinical data
AHFS/Drugs.com
Legal status
Routes of
administration
Oral
Identifiers
CAS Registry Number  Y
ATC code N06
PubChem CID:
DrugBank  Y
ChemSpider  Y
UNII  Y
KEGG  Y
Chemical data
Formula C16H18N4O2
Molecular mass 298.34 g/mol
 Y   

Nialamide (Niamid, Niamide, Nuredal, Surgex) is a non-selective, irreversible monoamine oxidase inhibitor (MAOI) of the hydrazine class that was used as an antidepressant.[1] It was withdrawn by Pfizer several decades ago due to the risk of hepatotoxicity.[2][3]

See also

References

  1. ^ William Andrew Publishing (1 December 2006). Pharmaceutical Manufacturing Encyclopedia, 3rd Edition. Elsevier. pp. 2935–.  
  2. ^ Shayne C. Gad (26 April 2012). Safety Pharmacology in Pharmaceutical Development: Approval and Post Marketing Surveillance, Second Edition. CRC Press. pp. 138–.  
  3. ^ Edward Shorter (28 September 2008). Before Prozac : The Troubled History of Mood Disorders in Psychiatry: The Troubled History of Mood Disorders in Psychiatry. Oxford University Press. pp. 137–.  


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