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Norepinephrine releasing agent

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Title: Norepinephrine releasing agent  
Author: World Heritage Encyclopedia
Language: English
Subject: Substituted phenethylamine, Pharmacology, Broxaterol, Mivazerol, Mabuterol
Collection: Drugs Acting on the Nervous System, Norepinephrine Releasing Agents, Taar1 Agonists, Vmat Inhibitors
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Norepinephrine releasing agent

A norepinephrine releasing agent (NRA) is a type of drug which induces the release of norepinephrine and epinephrine from the pre-synaptic neuron into the synapse. This in turn leads to increased extracellular concentrations of norepinephrine and epinephrine therefore an increase in adrenergic neurotransmission.[1][2]

Uses

NRAs are used for a variety of clinical indications including the following:

They are also used as recreational drugs, though this is typically reserved only for those that also induce the release of serotonin and/or dopamine like amphetamine, methamphetamine, MDMA, mephedrone, and 4-methylaminorex, among others.

Cathine and cathinone are NRAs found naturally in Catha edulis. Ephedrine and pseudoephedrine are also found naturally in Ephedra sinica. Both of these plants are used medicinally (and recreationally as well regarding the former). The endogenous trace amines phenethylamine and tyramine are NRAs found in many animals, including humans.

See also

References

  1. ^ Keith Parker; Laurence Brunton; Goodman, Louis Sanford; Lazo, John S.; Gilman, Alfred (2006). Goodman & Gilman's The Pharmacological Basis of Therapeutics (11 ed.). New York: McGraw-Hill. ISBN 0-07-142280-3. 
  2. ^ Thomas L. Lemke, David A. Williams, ed. (2007). Foye's Principles of Medicinal Chemistry (6 ed.). Baltimore: Lippincott Willams & Wilkins. ISBN 0-7817-6879-9. 


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