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Pnu-181731

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Pnu-181731

PNU-181731
Systematic (IUPAC) name
2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,7-a]indole
Identifiers
CAS Registry Number  YesY
PubChem CID:
Chemical data
Formula C12H14N2
Molecular mass 186.25 g/mol

PNU-181731 is a drug which acts as an agonist at serotonin 5-HT2 receptors,[1][2] with strongest binding affinity for the 5-HT2C subtype at 4.8nM, and weaker 5-HT2A affinity of 18nM. It has anxiolytic effects in animal studies with around one tenth the potency of alprazolam and no significant ataxia or other side effects noted.[3]

See also

References

  1. ^ Michael D Ennis et al. 2,3,4,5-Tetrahydro-1H-[1,4diazepino[1,7-a]indole compounds. US Patent 6734301, Priority date March 14, 2000]
  2. ^ Junya Shirai et al. Fused heterocyclic compound and use thereof. US Patent 8158617, Priority date May 16, 2006
  3. ^


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