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Phenprobamate

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Title: Phenprobamate  
Author: World Heritage Encyclopedia
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Subject: Lorbamate, Cyclarbamate, Febarbamate, Difebarbamate, Tetrabamate
Collection: Carbamates, Gabaa Receptor Positive Allosteric Modulators, Muscle Relaxants
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Phenprobamate

Phenprobamate
Systematic (IUPAC) name
3-Phenylpropylcarbamate
Clinical data
AHFS/Drugs.com
Pharmacokinetic data
Biological half-life 5 - 8 hours
Identifiers
CAS Registry Number  N
ATC code M03
PubChem CID:
ChemSpider  YesY
UNII  YesY
KEGG  YesY
ChEMBL  YesY
Chemical data
Formula C10H13NO2
Molecular mass
Documentation

 N   

Phenprobamate (Gamaquil, Isotonil) is a centrally acting skeletal muscle relaxant, with additional sedative and anticonvulsant effects. Overdose is similar to barbiturates. Its mechanism of action is probably similar to meprobamate. Phenprobamate was previously used in humans as an anxiolytic, and is still sometimes used in general anesthesia and for treating muscle cramps and spasticity. Phenprobamate is still used in some European countries, but it has generally been replaced by newer drugs. Phenprobamate is metabolized by oxidative degradation of the carbamate group and ortho-hydroxylation of the benzene ring, and is eliminated in urine by the kidneys.

Doses range from 400 to 800 mg, up to 3 times a day.

References

  • The Comparative Toxicogenomics Database: Phenprobamate
  • Chembank: Phenprobamate
  • Haemoperfusion may be useful in phenprobamate and polypharmacy intoxication of paediatric patients.Nephrology Dialysis Transplantation Volume 17, Number 5, Pp. 941. Letters:


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