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Title: Rds-127  
Author: World Heritage Encyclopedia
Language: English
Subject: PNU-99,194, List of dopaminergic drugs, Bay R 1531, Nafadotride, SKF-89,145
Publisher: World Heritage Encyclopedia


Systematic (IUPAC) name
Clinical data
Legal status
CAS number  YesY
ATC code None
ChemSpider  N
Chemical data
Formula C17H27NO2 
Mol. mass 277.402 g/mol

RDS-127 is a drug which is used in scientific research. It acts as a D2-like receptor agonist[1] and also has some serotonin and adrenergic agonist effects,[2][3][4][5] as well as some anticholinergic action,[6][7] and produces both anorectic and pro-sexual effects in animal studies.[8][9]

See also


  1. ^ Arnerić SP, Long JP, Williams M, et al. (January 1983). "RDS-127 (2-di-n-propylamino-4,7-dimethoxyindane): central effects of a new dopamine receptor agonist". The Journal of Pharmacology and Experimental Therapeutics 224 (1): 161–70.  
  2. ^ Arnerić SP, Roetker A, Long JP, Mott J, Barfknecht CF (June 1982). "Effects of semirigid methoxamine analogs on vascular smooth muscle: studies of methoxy-2-aminotetralin and 2-aminoindane derivatives". Archives Internationales De Pharmacodynamie et De Thérapie 257 (2): 263–73.  
  3. ^ Arnerić SP, Long JP (May 1984). "Evidence that a novel dopamine receptor agonist, RDS-127 [2-di-n-propylamino-4,7-dimethoxyindane] has some centrally mediated cardiovascular actions". The Journal of Pharmacy and Pharmacology 36 (5): 318–21.  
  4. ^ Clark JT, Smith ER (1986). "Failure of pimozide and metergoline to antagonize the RDS-127-induced facilitation of ejaculatory behavior". Physiology & Behavior 37 (1): 47–52.  
  5. ^ Rezaki YE, Ilhan M (1991). "Evaluation of alpha-adrenoceptor agonistic activity of RDS-127 (2-di-n-propylamino-4,7-dimethoxyindane) in rabbit and rat aortae". Archives Internationales De Pharmacodynamie et De Thérapie 310: 76–86.  
  6. ^ Sahin I, Ilhan M (1988). "The antimuscarinic activity of a dopamine receptor agonist (RDS-127) differentiates M2-muscarinic receptors of heart, ileum and trachea in guinea-pig". Archives Internationales De Pharmacodynamie et De Thérapie 296: 163–72.  
  7. ^ Sahin I, Tuncer M, Ilhan M (March 1990). "Dopamine receptor agonists, N,N-dipropyl-2-aminotetralin (TL-68) and 2-di-n-propylamino-4,7-dimethoxyindane (RDS-127) antagonize oxotremorine-induced tremors by antimuscarinic action in mice". Archives Internationales De Physiologie et De Biochimie 98 (1): 7–9.  
  8. ^ Arnerić SP, Roetker A, Long JP (September 1982). "Potent anorexic-like effects of RDS-127 (2-di-n-propylamino-4,7-dimethoxyindane) in the rat: a comparison with other dopamine-receptor agonists". Neuropharmacology 21 (9): 885–90.  
  9. ^ Kwong LL, Smith ER, Davidson JM, Peroutka SJ (October 1986). "Differential interactions of "prosexual" drugs with 5-hydroxytryptamine1A and alpha 2-adrenergic receptors". Behavioral Neuroscience 100 (5): 664–8.  

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