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Rh-34

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Title: Rh-34  
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Subject: 5-MeO-NBpBrT, 2,5-Dimethoxy-4-propylamphetamine, Lysergic acid 3-pentyl amide, 2CD-5EtO, Noribogaine
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Rh-34

RH-34
Systematic (IUPAC) name
3-[2-(2-methoxybenzylamino)ethyl]-1H-quinazoline-2,4-dione
Clinical data
Legal status
  • Uncontrolled
Routes ?
Identifiers
CAS number  N
ATC code None
PubChem
Chemical data
Formula C18H19N3O3 
Mol. mass 325.361 g/mol
 N   

RH-34 is a compound which acts as a potent and selective partial agonist for the 5-HT2A serotonin receptor subtype. It was derived by structural modification of the selective 5-HT2A antagonist ketanserin, with the 4-(p-fluorobenzoyl)piperidine moiety replaced by the N-(2-methoxybenzyl) pharmacophore found in such potent 5-HT2A agonists as NBOMe-2C-B and NBOMe-2C-I. This alteration was found to retain 5-HT2A affinity and selectivity, but reversed activity from an antagonist to a moderate efficacy partial agonist.[1][2][3]

See also

References

  1. ^ Ralf Heim. Synthese und Pharmakologie potenter 5-HT2A-Rezeptoragonisten mit N-2-Methoxybenzyl-Partialstruktur. Entwicklung eines neuen Struktur-Wirkungskonzepts. (German)
  2. ^ Maria Silva. Theoretical study of the interaction of agonists with the 5-HT2A receptor. Universität Regensburg, 2009.
  3. ^ Silva ME, Heim R, Strasser A, Elz S, Dove S (January 2011). "Theoretical studies on the interaction of partial agonists with the 5-HT(2A) receptor". Journal of Computer-aided Molecular Design 25 (1): 51–66.  


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