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Renal oncocytoma

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Renal oncocytoma

Renal oncocytoma
Classification and external resources
ICD-O: DiseasesDB 31956

A renal oncocytoma is a tumour of the kidney made up of oncocytes, a special kind of cell.[1][2]

Presentation

An oncocytoma is an epithelial tumor composed of oncocytes, large eosinophilic cells having small, round, benign-appearing nuclei with large nucleoli with excessive amounts of mitochondria.

Pathophysiology

Renal oncocytoma is thought to arise from the intercalated cells of collecting ducts of the kidney. It represent 5% to 15% of surgically resected renal neoplasms. Ultrastructurally, the eosinophilic cells have numerous mitochondria.

Diagnosis

In gross appearance, the tumors are tan or mahogany brown, well circumscribed and contain a central scar. They may achieve a large size (up to 12 cm in diameter).

The main differential diagnosis of renal oncocytoma is chromophobe renal cell carcinoma oncocytic variant, which like the renal oncocytoma has eosinophilic cytoplasm, but has perinuclear clearing and, typically, some degree of nuclear atypia.

Symptoms

Most cases of renal oncocytomas are asymptomatic, discovered incidentally (by chance) on a tomography or ultrasound of the abdomen. Some of the possible symptoms are: hematuria, flank pain, abdominal mass.

Treatment

Renal oncocytoma is considered benign, cured by nephrectomy. There are some familial cases in which these tumors are multicentric rather than solitary.[3] However, they may be resected to exclude a malignant tumor, e.g. renal cell carcinoma.

See also

Additional images

References

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