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Ro10-5824

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Title: Ro10-5824  
Author: World Heritage Encyclopedia
Language: English
Subject: List of dopaminergic drugs, Dinoxyline, Nafadotride, SKF-89,145, CY-208,243
Collection: Dopamine Agonists, Hoffmann-La Roche, Pyrimidines, Tetrahydropyridines
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Ro10-5824

Ro10-5824
Systematic (IUPAC) name
2-methyl-5-[(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)methyl]pyrimidin-4-amine
Clinical data
Legal status
?
Identifiers
CAS number
ATC code ?
PubChem
Chemical data
Formula C17H20N4 
Mol. mass 280.367 g/mol
 YesY   

Ro10-5824 is a drug which acts as a dopamine receptor partial agonist selective for the D4 subtype, and has nootropic effects in animal studies.[1][2]


References

  1. ^ Powell SB, Paulus MP, Hartman DS, Godel T, Geyer MA (March 2003). "RO-10-5824 is a selective dopamine D4 receptor agonist that increases novel object exploration in C57 mice". Neuropharmacology 44 (4): 473–81.  
  2. ^ Newman-Tancredi A, Heusler P, Martel JC, Ormière AM, Leduc N, Cussac D (May 2008). "Agonist and antagonist properties of antipsychotics at human dopamine D4.4 receptors: G-protein activation and K+ channel modulation in transfected cells". The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 11 (3): 293–307.  


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