World Library  
Flag as Inappropriate
Email this Article


Article Id: WHEBN0029148689
Reproduction Date:

Title: Ro5-4864  
Author: World Heritage Encyclopedia
Language: English
Subject: Translocator protein
Publisher: World Heritage Encyclopedia


Ro5-4864[1] (4'-Chlorodiazepam) is a drug which is a benzodiazepine derivative, the 4'-chloro derivative of diazepam. However unlike most benzodiazepine derivatives, Ro5-4864 lacks affinity for GABAA receptors and lacks typical benzodiazepine effects,[2] instead being sedative yet also convulsant and anxiogenic in effects.[3][4][5][6] Ro5-4864 was found to be a potent ligand for the "peripheral benzodiazepine receptor",[7] later renamed to mitochondrial translocator protein 18kDa (TSPO). Despite its convulsant effects, at lower doses Ro5-4864 has proved to be neuroprotective and has become widely used for research into the role of the TSPO protein in neurotoxicity,[8][9][10][11][12][13] as well as having analgesic [14] and possible antidepressant,[15] cardioprotective and anti-cancer effects.[16][17][18][19]

See also

  • Diclazepam (2'-Chlorodiazepam)
  • PK-11195


This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.

Copyright © World Library Foundation. All rights reserved. eBooks from World eBook Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.