World Library  
Flag as Inappropriate
Email this Article

Skf-77,434

Article Id: WHEBN0026822498
Reproduction Date:

Title: Skf-77,434  
Author: World Heritage Encyclopedia
Language: English
Subject: List of dopaminergic drugs, Dinoxyline, Nafadotride, SKF-89,145, 8-OH-PBZI
Collection:
Publisher: World Heritage Encyclopedia
Publication
Date:
 

Skf-77,434

SKF-77,434
Systematic (IUPAC) name
3-allyl-1-phenyl-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol
Clinical data
Legal status
?
Identifiers
CAS number
ATC code ?
PubChem
Chemical data
Formula C19H21NO2 
Mol. mass 295.375 g/mol
 YesY   

SKF-77,434 is a drug which acts as a selective dopamine D1 receptor partial agonist, and has stimulant and anorectic effects. Unlike other D1 agonists with higher efficacy such as SKF-81,297 and 6-Br-APB, SKF-77,434 does not maintain self-administration in animal studies, and so has been researched as a potential treatment for cocaine addiction.[1][2][3][4][5][6][7]

References

  1. ^ Grech, D. M.; Spealman, R. D.; Bergman, J. (1996). "Self-administration of D1 receptor agonists by squirrel monkeys". Psychopharmacology 125 (2): 97–104.  
  2. ^ Weed, M. R.; Paul, I. A.; Dwoskin, L. P.; Moore, S. E.; Woolverton, W. L. (1997). "The relationship between reinforcing effects and in vitro effects of D1 agonists in monkeys". The Journal of Pharmacology and Experimental Therapeutics 283 (1): 29–38.  
  3. ^ Platt, D. M.; Rowlett, J. K.; Spealman, R. D. (2000). "Dissociation of cocaine-antagonist properties and motoric effects of the D1 receptor partial agonists SKF 83959 and SKF 77434". The Journal of Pharmacology and Experimental Therapeutics 293 (3): 1017–1026.  
  4. ^ Platt, D. M.; Rowlett, J. K.; Spealman, R. D. (2001). "Modulation of cocaine and food self-administration by low- and high-efficacy D1 agonists in squirrel monkeys". Psychopharmacology 157 (2): 208–216.  
  5. ^ Mutschler, N. H.; Bergman, J. (2002). "Effects of chronic administration of the D1 receptor partial agonist SKF 77434 on cocaine self-administration in rhesus monkeys". Psychopharmacology 160 (4): 362–370.  
  6. ^ Desai, R. I.; Terry, P.; Katz, J. L. (2005). "A comparison of the locomotor stimulant effects of D1-like receptor agonists in mice". Pharmacology, Biochemistry, and Behavior 81 (4): 843–848.  
  7. ^ Katz, J. L.; Kopajtic, T. A.; Terry, P. (2006). "Effects of dopamine D1-like receptor agonists on food-maintained operant behavior in rats". Behavioural Pharmacology 17 (4): 303–309.  


This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and USA.gov, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for USA.gov and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
 
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
 
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.
 



Copyright © World Library Foundation. All rights reserved. eBooks from World eBook Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.