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Snc-80

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Snc-80

SNC-80
Systematic (IUPAC) name
4-[(R)-[(2S,5R)-4-allyl-2,5-dimethylpiperazin-1-yl](3-methoxyphenyl)methyl]-N,N-diethylbenzamide
Clinical data
Legal status
?
Identifiers
CAS number  N
ATC code ?
PubChem
IUPHAR ligand
ChemSpider  YesY
ChEMBL  YesY
Synonyms SNC-80
Chemical data
Formula C28H39N3O2 
Mol. mass 449.63 g/mol
 N   

SNC-80 is an opioid analgesic drug that selectively activates μ–δ opioid receptor heteromers[1] and is used in scientific research.[2] It was discovered in 1994.[3]

SNC-80 was the first non-peptide drug developed that was regarded as a highly selective agonist for the δ-opioid receptor.[4] It has been shown to produce useful analgesic,[5] antidepressant[6] and anxiolytic effects in animal studies,[7][8] but its usefulness is limited by producing convulsions at high doses,[9] and so SNC-80 is not used medically, although it is a useful drug in scientific research.

References

  1. ^ Metcalf MD, Yekkirala AS, Powers MD, Kitto KF, Fairbanks CA, Wilcox GL, Portoghese PS (July 2012). "The δ opioid receptor agonist SNC80 selectively activates heteromeric μ-δ opioid receptors". ACS Chem Neurosci 3 (7): 505–9.  
  2. ^ Calderon SN, Coop A (2004). "SNC 80 and related delta opioid agonists". Curr. Pharm. Des. 10 (7): 733–42.  
  3. ^ Calderon SN, Rothman RB, Porreca F, Flippen-Anderson JL, McNutt RW, Xu H, Smith LE, Bilsky EJ, Davis P, Rice KC (July 1994). "Probes for narcotic receptor mediated phenomena. 19. Synthesis of (+)-4-[(alpha R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3- methoxybenzyl]-N,N-diethylbenzamide (SNC 80): a highly selective, nonpeptide delta opioid receptor agonist". J. Med. Chem. 37 (14): 2125–8.  
  4. ^ Bilsky EJ, Calderon SN, Wang T, Bernstein RN, Davis P, Hruby VJ, McNutt RW, Rothman RB, Rice KC, Porreca F (April 1995). "SNC 80, a selective, nonpeptidic and systemically active opioid delta agonist". J. Pharmacol. Exp. Ther. 273 (1): 359–66.  
  5. ^ Gallantine EL, Meert TF (July 2005). "A comparison of the antinociceptive and adverse effects of the mu-opioid agonist morphine and the delta-opioid agonist SNC80". Basic Clin. Pharmacol. Toxicol. 97 (1): 39–51.  
  6. ^ Jutkiewicz EM, Rice KC, Traynor JR, Woods JH (November 2005). "Separation of the convulsions and antidepressant-like effects produced by the delta-opioid agonist SNC80 in rats". Psychopharmacology (Berl.) 182 (4): 588–96.  
  7. ^ Perrine SA, Hoshaw BA, Unterwald EM (April 2006). "Delta opioid receptor ligands modulate anxiety-like behaviors in the rat". Br. J. Pharmacol. 147 (8): 864–72.  
  8. ^ Saitoh A, Kimura Y, Suzuki T, Kawai K, Nagase H, Kamei J (July 2004). "Potential anxiolytic and antidepressant-like activities of SNC80, a selective delta-opioid agonist, in behavioral models in rodents". J. Pharmacol. Sci. 95 (3): 374–80.  
  9. ^ Danielsson I, Gasior M, Stevenson GW, Folk JE, Rice KC, Negus SS (October 2006). "Electroencephalographic and convulsant effects of the delta opioid agonist SNC80 in rhesus monkeys". Pharmacol. Biochem. Behav. 85 (2): 428–34.  



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