World Library  
Flag as Inappropriate
Email this Article

Serotonergic psychedelic

Article Id: WHEBN0030862497
Reproduction Date:

Title: Serotonergic psychedelic  
Author: World Heritage Encyclopedia
Language: English
Subject: Psychedelic drug, Obsessive–compulsive disorder, 4-HO-MiPT, Recreational use of ketamine, 25I-NBOMe
Collection: Psychedelic Drugs
Publisher: World Heritage Encyclopedia
Publication
Date:
 

Serotonergic psychedelic

Serotonergic psychedelics (also known as serotonergic hallucinogens) are a class of hallucinogenic drugs with a method of action strongly tied to the neurotransmitter serotonin. Serotonin (often referred to as 5-HT, short for its full chemical name 5-hydroxytryptamine) is a naturally occurring neurotransmitter which is tied to positive mood, certain involuntary muscle control, and countless other functions, many of which are not yet fully understood.

Contents

  • Method of action 1
  • Examples 2
  • Recreational uses 3
  • References 4
  • External resources 5

Method of action

While the method of action of serotonergic psychedelics is not fully understood, serotonergic psychedelics are known to show affinities for various 5-HT receptors in different ways and levels, and may be classified by their activity at different 5-HT sub-sites, such as 5-HT1A, 5-HT1B, 5-HT2A, etc. Many serotonergic psychedelics, such as the family of tryptamines, have very strong structural similarities to serotonin itself, which partially explains the affinity for certain 5-HT sites. It is almost unanimously agreed that serotonergic psychedelics produce their effect by acting as strong partial agonists at the 5-HT2A receptors. How this produces the psychedelic experience is unclear, but it is likely that it acts by increasing excitation in the cortex, possibly by specifically facilitating input from the thalamus, the major relay for sensory information input to the cortex.[1] Worth noting is that selective serotonin reuptake inhibitors (a class of antidepressants including Paxil, Prozac, and Zoloft) can increase the dosage required for hallucinogenic effects of serotonergic psychedelics, in some people, based on anecdotal reports. Some users, however, have found this to be entirely untrue for them.

Examples

Examples of serotonergic psychedelics include DMT, LSD, psilocybin, and mescaline. The tryptamine psychedelics, such as DMT and psilocybin, structurally resemble serotonin itself. The phenethylamine psychedelics on the other hand, such as compounds of the 2C family, more closely resemble the neurotransmitter dopamine.

Recreational uses

The most widely known use of serotonergic psychedelics is as recreational drugs, providing the user with a psychedelic experience known colloquially as a trip.

References

  1. ^ Nichols, David E. (2004). "Hallucinogens". Pharmacology & Therapeutics 101 (2): 131–81.  

External resources

  • eadaches Research Library - 5HT and HallucinogensHluster Cnderstanding Urganization for O (Archive.org index, Aug 28, 2005)
  • Cluster Busters
This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and USA.gov, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for USA.gov and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
 
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
 
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.
 



Copyright © World Library Foundation. All rights reserved. eBooks from World eBook Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.