Signet ring cell carcinoma

Signet ring cell carcinoma
Classification and external resources
ICD-O: MeSH D018279

Signet ring cell carcinoma is an epithelial malignancy characterized by the histologic appearance of signet ring cells.

It is a form of adenocarcinoma,[1] and it is most often found in the glandular cells of the stomach, but it may develop in other areas of the body.[2] eg. the prostate,[3] bladder, gallbladder,[4] breast, colon,[5] ovarian stroma and testis.[6]

Some cases (not all) are inherited, and these cases are often caused by mutations in the CDH1 gene.[7]


The pattern of metastases is different for gastric signet cell carcinoma than for intestinal-type gastric carcinoma. In cases where gastric signet cell carcinoma metastasizes, it tends to spread to peritoneal metastases, lymphatic permeation of the lungs, and to the ovaries, creating Krukenberg tumors.[8]

Histologic appearance

Main article: signet ring cell

Signet ring cells resemble signet rings because a large vacuole full of mucin displaces the nucleus to the periphery.

Prognosis, by organ

In a group of 154 Japanese patients the overall median survival time was 12.7 months and the 5-year survival rate was 9.4%.[5]

Additional images


External links

  • What is a signet cell cancer

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