Signet ring cell carcinoma

Signet ring cell carcinoma
Classification and external resources
ICD-O: MeSH D018279

Signet ring cell carcinoma is an epithelial malignancy characterized by the histologic appearance of signet ring cells.

It is a form of adenocarcinoma,[1] and it is most often found in the glandular cells of the stomach, but it may develop in other areas of the body.[2] eg. the prostate,[3] bladder, gallbladder,[4] breast, colon,[5] ovarian stroma and testis.[6]

Some cases (not all) are inherited, and these cases are often caused by mutations in the CDH1 gene.[7]

Metastases

The pattern of metastases is different for gastric signet cell carcinoma than for intestinal-type gastric carcinoma. In cases where gastric signet cell carcinoma metastasizes, it tends to spread to peritoneal metastases, lymphatic permeation of the lungs, and to the ovaries, creating Krukenberg tumors.[8]

Histologic appearance

Main article: signet ring cell

Signet ring cells resemble signet rings because a large vacuole full of mucin displaces the nucleus to the periphery.

Prognosis, by organ

Colorectal
In a group of 154 Japanese patients the overall median survival time was 12.7 months and the 5-year survival rate was 9.4%.[5]

Additional images

References

External links

  • What is a signet cell cancer


This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and USA.gov, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for USA.gov and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
 
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
 
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.