World Library  
Flag as Inappropriate
Email this Article

SoRI-9409

Article Id: WHEBN0033546897
Reproduction Date:

Title: SoRI-9409  
Author: World Heritage Encyclopedia
Language: English
Subject: List of opioids, Kobret, 6β-Naltrexol-d4, Hemorphin, Naloxonazine
Collection:
Publisher: World Heritage Encyclopedia
Publication
Date:
 

SoRI-9409

SoRI-9409
Clinical data
Legal status
?
Identifiers
CAS number  YesY
ATC code ?
PubChem
Chemical data
Formula C29H27ClN2O3 
Mol. mass 486.988 g/mol
 YesY   

SoRI-9409 is a mixed mu opioid receptor partial agonist and delta opioid receptor antagonist, used in biomedical research. It produces moderate analgesic effects without development of tolerance and with reduced withdrawal symptoms compared to standard opioid analgesics,[1] as well as showing anti-addictive effects that may be useful in the treatment of alcoholism.[2][3]

References

  1. ^ Wells JL, Bartlett JL, Ananthan S, Bilsky EJ. In vivo pharmacological characterization of SoRI 9409, a nonpeptidic opioid mu-agonist/delta-antagonist that produces limited antinociceptive tolerance and attenuates morphine physical dependence. Journal of Pharmacology and Experimental Therapeutics. 2001 May;297(2):597-605. PMID 11303048
  2. ^ Nielsen CK, Simms JA, Pierson HB, Li R, Saini SK, Ananthan S, Bartlett SE. A novel delta opioid receptor antagonist, SoRI-9409, produces a selective and long-lasting decrease in ethanol consumption in heavy-drinking rats. Biological Psychiatry. 2008 Dec 1;64(11):974-81. PMID 18774553
  3. ^ Nielsen CK, Simms JA, Bito-Onon JJ, Li R, Ananthan S, Bartlett SE. The delta opioid receptor antagonist, SoRI-9409, decreases yohimbine stress-induced reinstatement of ethanol-seeking. Addiction Biology. 2011 Feb 11. doi:10.1111/j.1369-1600.2010.00295.x. PMID 21309957


This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and USA.gov, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for USA.gov and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
 
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
 
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.
 



Copyright © World Library Foundation. All rights reserved. eBooks from World eBook Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.