World Library  
Flag as Inappropriate
Email this Article

Tricyanoaminopropene

Article Id: WHEBN0018238940
Reproduction Date:

Title: Tricyanoaminopropene  
Author: World Heritage Encyclopedia
Language: English
Subject: Nootropics, SIB-1553A, Adafenoxate, PRX-03140, TB-21007
Collection:
Publisher: World Heritage Encyclopedia
Publication
Date:
 

Tricyanoaminopropene

Tricyanoaminopropene
Systematic (IUPAC) name
1,1,3-tricyano-2-amino-1-propene
Clinical data
Trade names Triap
Legal status
  • Investigational
Identifiers
CAS Registry Number  YesY
PubChem CID:
Chemical data
Formula C6H4N4
Molecular mass 132.123 g/mol
 YesY   

Tricyanoaminopropene (TRIAP, TCAP, Malononitrile Dimer, 1,1,3-tricyano-2-amino-1-propene) is a nootropic drug which mimics the function of nerve growth factor and increases the growth of nerves and tissue regeneration both in isolated tissues[1] and in vivo. It stimulates the action of the enzyme choline acetyltransferase, resulting in increased acetylcholine production.[2] This then results in increased synthesis of RNA in many different tissues in the body.[3] However it also suppresses the production of thyroxine, causing temporary hypothyroidism which returns to normal once the drug is discontinued.[4]

Tricyanoaminopropene reduces the amnesia produced by electroconvulsive shock,[5] and animal tests suggested nootropic activity,[6][7][8] but no beneficial effect was found when it was tested in mentally retarded children,[9] and administration to pregnant rats actually reduced learning ability in their young because of its anti-thyroid hormone effects.[10] This drug thus produces two effects which oppose each other, with the nootropic effect from the increased acetylcholine production cancelled out by the opposite effect produced by the decrease in production of thyroxine. It is not known whether the efficacy of the drug could be improved by supplementation with additional thyroxine or equivalent drugs.

See also

References

  1. ^ Paul JW, Quach TT, Duchemin AM, Schrier BK, DaVanzo JP. 1,1,3 tricyano-2-amino-1-propene (Triap): a small molecule which mimics or potentiates nerve growth factor. Brain Research. Developmental Brain Research. 1990 Aug 1;55(1):21-7. PMID 2208638
  2. ^ Paul JW, DaVanzo JP. 1,1,3 Tricyano-2-amino-1-propene (Triap) stimulates choline acetyltransferase activity in vitro and in vivo. Brain Research. Developmental Brain Research. 1992 Jun 19;67(2):113-20. PMID 1511511
  3. ^ Dhindsa KS, Enesco HE. Radioautographic study of the effect of malononitrile dimer on RNA synthesis in mice. Acta Anatomica (Basel). 1978;100(1):44-50. PMID 899675
  4. ^ Dhindsa KS. Histological changes in the thyroid gland of the mouse following treatment with 1, 1, 3-tricyano-2-amino-1-propene. Acta Anatomica (Basel). 1980;106(4):468-72. PMID 7386168
  5. ^ Essman WB. Effect of tricyanoaminopropene on the amnesic effect of electroconvulsive shock. Psychopharmacology (Berlin. 1966 Jan;9(5):426-433 doi:10.1007/BF00406452.
  6. ^ Rahwan RG. The biochemical and pharmacological basis of learning and memory. Inflammation Research. 1971 Aug;2(2):87-102.
  7. ^ Banfi S, Cornelli U, Fonio W, Dorigotti L. A screening method for substances potentially active on learning and memory. Journal of Pharmacological Methods. 1982 Dec;8(4):255-63. PMID 7154677
  8. ^ STUDIES OF THE EFFECTS OF MANIPULATION OF BRAIN METABOLISM ON LEARNING. I. VITAMIN B12. II. MAGNESIUM PEMOLINE (CYLERT). III. MALONONITRILE DIMER (U9189). IV. ANODAL POLARIZATION.
  9. ^ Panzer JD, Atkinson WH. Tricyanoaminopropene (TCAP): Lack of Improvement of Mentation in Mentally Retarded Children. Psychosomatics. 1969 Mar-Apr;10(2):136-40. PMID 4181970
  10. ^ Davenport JW. Cretinism in Rats: Enduring Behavioral Deficit Induced by Tricyanoaminopropene. Science 1970 Feb;167(3920):1007-1009.
This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and USA.gov, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for USA.gov and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
 
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
 
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.
 



Copyright © World Library Foundation. All rights reserved. eBooks from World eBook Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.