World Library  
Flag as Inappropriate
Email this Article

Tutin (toxin)

Article Id: WHEBN0021543730
Reproduction Date:

Title: Tutin (toxin)  
Author: World Heritage Encyclopedia
Language: English
Subject: Nipecotic acid, Pitrazepin, Quisqualamine, Tutu (plant), GABA transaminase inhibitor
Collection:
Publisher: World Heritage Encyclopedia
Publication
Date:
 

Tutin (toxin)

Tutin (toxin)
Systematic (IUPAC) name
2a,3a-epoxy- 3a,4a,5,6,7,7a-hexahydro- 3aα,6β,7β-trihydroxy- 5α-isopropyl- 7aα-methylspiro (indan-1,2'-oxirane)- γ-lactone
Clinical data
Legal status
?
Identifiers
CAS number  YesY
ATC code None
PubChem
Chemical data
Formula C15H18O6 
Mol. mass 294.299 g/mol
 YesY   

Tutin is a poisonous plant derivative found in the New Zealand tutu plant (Coriaria arborea, Coriaria genus, several different species). It acts as a potent antagonist of the glycine receptor,[1] and has powerful convulsant effects.[2] It is used in scientific research into the glycine receptor, and is also sometimes associated with outbreaks of toxic honey poisoning when bees feed honeydew exudate from the sap-sucking insect commonly known as the passion vine hopper, when these vine hoppers (Scolypopa australis) have been feeding on the sap of tutu bushes. Toxic honey is a rare event and is more likely to occur when comb honey is eaten directly from a hive that has been harvesting honeydew from passion vine hoppers feeding on tutu plants.[3]

References

  1. ^ Fuentealba J, Guzmán L, Manríquez-Navarro P, Pérez C, Silva M, Becerra J, Aguayo LG. Inhibitory effects of tutin on glycine receptors in spinal neurons. European Journal of Pharmacology. 2007 Mar 15;559(1):61-4. PMID 17303114
  2. ^ Zhou H, Tang YH, Zheng Y. A new rat model of acute seizures induced by tutin. Brain Research. 2006 May 30;1092(1):207-13. PMID 16674929
  3. ^ Background on toxic honey. New Zealand Food Safety Authority.



This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and USA.gov, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for USA.gov and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
 
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
 
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.
 



Copyright © World Library Foundation. All rights reserved. eBooks from World eBook Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.