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Title: U-92,016-a  
Author: World Heritage Encyclopedia
Language: English
Subject: 5-HT1A receptor, RS-56812, 6-Chloro-5-ethoxy-N-(pyridin-2-yl)indoline-1-carboxamide, BRL-54443, SB-215505
Publisher: World Heritage Encyclopedia


Systematic (IUPAC) name
Clinical data
Legal status
CAS number  YesY
ATC code ?
ChemSpider  YesY
Chemical data
Formula C19H25N3 
Mol. mass 295.421 g/mol

U-92,016-A is a psychoactive drug and research chemical used in scientific studies. It acts as a potent, high efficacy, and selective 5-HT1A receptor full agonist with a long duration of action.[1][2] It has been suggested that it could be developed as an anxiolytic or antidepressant drug.[1]


  1. ^ a b Romero AG, Leiby JA, McCall RB, Piercey MF, Smith MW, Han F. (1993). "Novel 2-substituted tetrahydro-3H-benz[e]indolamines: highly potent and selective agonists acting at the 5-HT1A receptor as possible anxiolytics and antidepressants.". J Med Chem. 36 (15): 2066–2074.  
  2. ^ McCall RB, Romero AG, Bienkowski MJ, Harris DW, McGuire JC, Piercey MF, Shuck ME, Smith MW, Svensson KA, Schreur PJ, et al. (1994). "Characterization of U-92016A as a selective, orally active, high intrinsic activity 5-hydroxytryptamine1A agonist.". J Pharmacol Exp Ther. 271 (2): 875–883.  

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