World Library  
Flag as Inappropriate
Email this Article

Ub-165

Article Id: WHEBN0024500079
Reproduction Date:

Title: Ub-165  
Author: World Heritage Encyclopedia
Language: English
Subject: TC-2216, ABT-202, AR-R17779, A-366,833, Sazetidine A
Collection:
Publisher: World Heritage Encyclopedia
Publication
Date:
 

Ub-165

UB-165
Systematic (IUPAC) name
(1R,6R)-5-(6-chloropyridin-3-yl)-9-azabicyclo[4.2.1]non-4-ene
Clinical data
Legal status
?
Identifiers
CAS number
ATC code ?
PubChem
Chemical data
Formula C13H15ClN2 
Mol. mass 234.724
 YesY   

UB-165 is a drug which acts as an agonist at neural nicotinic acetylcholine receptors being a full agonist at α3β2 and a partial agonist for the α4β2* isoform. It is used to study the role of this receptor subtype in the release of dopamine and noradrenaline in the brain,[1][2] and has also been used as a lead compound to derive a number of other selective nicotinic receptor ligands.[3][4][5][6]

References

  1. ^ Sharples, C. G.; Kaiser, P.; Soliakov, L.; Marks, M. J.; Collins, A. C.; Washburn, M.; Wright, E.; Spencer, J. A.; Gallagher, T.; Whiteaker, P.; Wonnacott, S. (2000). "UB-165: a novel nicotinic agonist with subtype selectivity implicates the alpha4beta2* subtype in the modulation of dopamine release from rat striatal synaptosomes". Journal of Neuroscience 20 (8): 2783–2791.  
  2. ^ Cao, Y.; Surowy, C.; Puttfarcken, P. (2005). "Nicotinic acetylcholine receptor-mediated 3Hdopamine release from hippocampus". The Journal of Pharmacology and Experimental Therapeutics 312 (3): 1298–1304.  
  3. ^ Gohlke, H.; Gündisch; Schwarz; Seitz; Tilotta; Wegge (2002). "Synthesis and nicotinic binding studies on enantiopure diazine analogues of the novel (2-chloro-5-pyridyl)-9-azabicyclo4.2.1non-2-ene UB-165".  
  4. ^ Sharples, C. G.; Karig; Simpson; Spencer; Wright; Millar; Wonnacott; Gallagher (2002). "Synthesis and pharmacological characterization of novel analogues of the nicotinic acetylcholine receptor agonist (+/-)-UB-165".  
  5. ^ Sutherland, A.; Gallagher, T.; Sharples, C.; Wonnacott, S. (2003). "Synthesis of two fluoro analogues of the nicotinic acetylcholine receptor agonist UB-165". The Journal of Organic Chemistry 68 (6): 2475–2478.  
  6. ^ Karig, G.; Large; Sharples; Sutherland; Gallagher; Wonnacott (2003). "Synthesis and nicotinic binding of novel phenyl derivatives of UB-165. Identifying factors associated with alpha7 selectivity". Bioorganic & Medicinal Chemistry Letters 13 (17): 2825–2828.  


This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and USA.gov, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for USA.gov and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
 
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
 
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.
 



Copyright © World Library Foundation. All rights reserved. eBooks from World eBook Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.