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Valproate

Valproic acid
Systematic (IUPAC) name
2-Propylpentanoic acid
Clinical data
Trade names Depakote, Epilim, Stavzor, Vilapro
AHFS/Drugs.com
MedlinePlus
Licence data US FDA:
Pregnancy cat.
Legal status
Routes Oral, intravenous
Pharmacokinetic data
Bioavailability Rapid absorption
Protein binding 80-90%[1]
Metabolism Hepaticglucuronide conjugation 30–50%, mitochondrial β-oxidation over 40%
Half-life 9–16 hours[1]
Excretion Urine (30-50%)[1]
Identifiers
CAS number  YesY
ATC code N03
PubChem
DrugBank
ChemSpider  YesY
UNII  YesY
KEGG  YesY
ChEBI  YesY
ChEMBL  YesY
NIAID ChemDB
Synonyms 2-Propylvaleric acid
Chemical data
Formula C8H16O2 
Mol. mass 144.211 g/mol
 YesY   

Valproic acid (VPA, valproate), an acidic chemical compound, has found clinical use as an anticonvulsant and mood-stabilizing drug, primarily in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches. VPA is a liquid at room temperature, but it can be reacted with a base such as sodium hydroxide to form the salt sodium valproate, which is a solid.

The acid, salt, or a mixture of the two (health system.[2]

Contents

  • Medical uses 1
  • Adverse effects 2
    • By frequency 2.1
    • Other possible side effects 2.2
    • Pregnancy 2.3
    • Contraindications 2.4
    • Interactions 2.5
    • Overdose and toxicity 2.6
  • Mechanism of action 3
  • History 4
  • Society and culture 5
    • Approval status 5.1
  • Formulations 6
  • Chemistry 7
  • See also 8
  • References 9
  • Further reading 10
  • External links 11

Medical uses

Its primary use in medicine is in the treatment of epilepsy, bipolar mania and migraine prophylaxis.[3] Valproate products are also used to treat manic or mixed episodes associated with bipolar disorder.[4] Off-label uses include impulse control disorders, suggested by recent evidence of efficacy in controlling this adverse effect of Parkinson's Disease medical therapy.[5] Recently, it has been trialled in the treatment of HIV and cancer, owing to its histone deacetylase-inhibiting effects.[6] Valproate has a broad spectrum of anticonvulsant activity, although it is primarily used as a first-line treatment for tonic-clonic seizures, absence seizures and myoclonic seizures and as a second-line treatment for partial seizures and infantile spasms.[3][7] It has also been successfully given intravenously to treat status epilepticus.[8][9][10]

Adverse effects

The most common adverse effects of valproic acid are digestive complaints like diarrhea, nausea, vomiting and indigestion; vision problems like seeing double or lazy eye; hormonal disturbances (increased testosterone production in females and menstrual irregularities), hair loss, memory problems, weight gain, infections, low platelet count (which can make one bleed more easily), dizziness, drowsiness, tremor and headache.[3][11] Less common, yet serious side effects include liver damage, brittle bones (becomes far more common with long-term use), polycystic ovaries, movement disorders (which may be irreversible like tardive dyskinesia), psychiatric/neurologic disturbances like hallucinations, anxiety and confusion; swollen pancreas, low body temperature and potentially life-threatening blood abnormalities.[3]

By frequency

Sources:[1][3][11][12]
Very common (>10% frequency):

  • Elevated aminotransferase concentrations (dose-related; indicative of liver injury)

Common (1-10% frequency):

  • High blood levels of ammonia without symptoms

Uncommon (0.1-1% frequency):

  • Peripheral oedema
  • SIADH

Rare (<0.1% frequency):

  • Liver failure
  • Pancreatitis (these two usually occur in first 6 months and can be fatal)
  • Leucopenia (low white blood cell count)
  • Neutropenia (low neutrophil count)
  • Pure red cell aplasia
  • Agranulocytosis
  • Extrapyramidal syndrome (including parkinsonism, may be reversible)
  • Brain problems due to high ammonia levels
  • Hypothermia
  • Hypersensitivity reactions including multi-organ hypersensitivity syndrome
  • Eosinophilic pleural effusion
  • Bone fractures (reduced BMD with long-term use)

Other possible side effects

There is evidence that valproic acid may cause premature growth plate ossification in children and adolescents, resulting in short stature.[13][14][15][16] Valproic acid can also cause mydriasis, a protracted dilation of the pupils[17]

Pregnancy

Valproate causes birth defects; exposure during pregnancy is associated with about three times as many major anomalies as usual, mainly spina bifida and, more rarely, with several other defects, possibly including a "valproate syndrome".[18] Characteristics of this valproate syndrome include facial features that tend to evolve with age, including trigonocephaly, tall forehead with bifrontal narrowing, epicanthic folds, medial deficiency of eyebrows, flat nasal bridge, broad nasal root, anteverted nares, shallow philtrum, long upper lip and thin vermillion borders, thick lower lip and small downturned mouth.[19]

Women who intend to become pregnant should switch to a different drug if possible.[20] Women who become pregnant while taking valproate should be warned that it causes birth defects and cognitive impairment in the newborn, especially at high doses (although vaproate is sometimes the only drug that can control seizures, and seizures in pregnancy could have even worse consequences.) They should take high-dose folic acid and be offered antenatal screening (alpha-fetoprotein and second-trimester ultrasound scans), although screening and scans do not find all birth defects.[21]

Valproate can cause neural tube defects. Folic acid supplements may reduce the risk of birth defects, however. A recent study showed children of mothers taking valproate during pregnancy are at risk for significantly lower IQs.[22][23][24] Maternal valproate use during pregnancy has been associated with a significantly higher risk of autism in the offspring.[25] Exposure of the human embryo to valproic acid is associated with risk of autism, and it is possible to duplicate features characteristic of autism by exposing rat embryos to valproic acid at the time of neural tube closure.[26] Valproate exposure on embryonic day 11.5 led to significant local recurrent connectivity in the juvenile rat neocortex, consistent with the underconnectivity theory of autism.[27] A 2009 study found that the 3 year old children of pregnant women taking valproate had an IQ nine points lower than that of a well-matched control group. However, further research in older children and adults is needed.[28][29][30]

Contraindications

Contraindications include:[12]

  • Pregnancy
  • Pre-existing acute or chronic hepatic dysfunction or family history of severe hepatitis, particularly medicine related.
  • Known hypersensitivity to valproate or any of the excipients used in the preparation
  • Urea cycle disorders
  • Hepatic porphyria
  • Hepatotoxicity[12]
  • Mitochondrial disease[12]
  • Pancreatitis[12]

Interactions

Valproate inhibits CYP2C9, glucuronyl transferase, and epoxide hydrolase and is highly protein bound and hence may interact with drugs that are substrates for any of these enzymes or are highly protein bound themselves.[12] It may also potentiate the CNS depressant effects of alcohol.[12] It should not be given in conjunction with other antiepileptics due to the potential for reduced clearance of other antiepileptics (including carbamazepine, lamotrigine, phenytoin and phenobarbitone) and itself.[12] It may also interact with:[12]

  • Anticoagulants, due to its ability to prolong the bleeding time.
  • Psychotropic agents; potential pharmacokinetic interactions.
  • Benzodiazepines; may potentiate CNS depression and there are possible pharmacokinetic interactions.
  • Ethosuximide; potential for ethosuximide toxicity.
  • Primidone; may reduce pyrimidone's clearance leading to toxicity.
  • Zidovudine; may raise its (zidovudine's) serum concentration and lead to toxicity.
  • Aspirin; may displace valproate from plasma proteins, leading to increased plasma concentrations. Also interferes with valproate's metabolism.
  • Felbalmate; may increase plasma concentrations of valproate.
  • Mefloquine; potential for increased valproate metabolism combined with the direct epileptogenic effects of mefloquine.
  • Cimetidine; inhibits valproate's metabolism in the liver, hence leading to reduced plasma concentrations of valproate.
  • Erythromycin; inhibits valproate's metabolism in the liver, hence leading to increased plasma concentrations of valproate.
  • Carbapenem antibiotics; reduces valproate levels, potentially leading to seizures.

Overdose and toxicity

Excessive amounts of valproic acid can result in tremor, stupor, respiratory depression, coma, metabolic acidosis, and death. Overdosage in children is usually of an accidental nature, whereas with adults it is more likely to be an intentional act. In general, serum or plasma valproic acid concentrations are in a range of 20–100 mg/l during controlled therapy, but may reach 150–1500 mg/l following acute poisoning. Monitoring of the serum level is often accomplished using commercial immunoassay techniques, although some laboratories employ gas or liquid chromatography.[31] In contrast to other antiepileptic drugs, at present there is little evidence favorable evidence for salivary therapeutic drug monitoring. Salivary levels of valproic acid correlate poorly with serum levels, at least in part due to valproate's weak acid property (pKa of 4.9).[32]

In severe intoxication, hemoperfusion or hemofiltration can be an effective means of hastening elimination of the drug from the body.[33][34] Supplemental L-carnitine is indicated in patients having an acute overdose[35][36] and also prophylactically[35] in high risk patients. Acetyl-L-carnitine lowers hyperammonemia less markedly[37] than L-carnitine.

Mechanism of action

Although the mechanism of action of valproate is not fully understood,[12] it has recently been shown to protect against a seizure-induced reduction in phosphatidylinositol (3,4,5)-trisphosphate (PIP3) as a potential therapeutic mechanism.[38] In addition, its anticonvulsant effect has been attributed to the blockade of voltage-dependent sodium channels and increased brain levels of gamma-aminobutyric acid (GABA).[12] The GABAergic effect is also believed to contribute towards the anti-manic properties of valproate.[12] In animals, sodium valproate raises cerebral and cerebellar levels of the inhibitory synaptic transmitter, GABA, possibly by inhibiting GABA degradative enzymes, such as GABA transaminase, succinate-semialdehyde dehydrogenase and by inhibiting the re-uptake of GABA by neuronal cells.[12] It also possesses histone deacetylase-inhibiting effects. The inhibition of histone deacetylase, by promoting more transcriptionally active chromatin structures, likely presents the epigenetic mechanism for regulation of many of the neuroprotective effects attributed to valproic acid. Intermediate molecules mediating these effects include VEGF, BDNF, and GDNF. [39][40]

History

Valproic acid was first synthesized in 1882 by B.S. Burton as an pentylenetetrazol-induced convulsions in laboratory rats.[42] It was approved as an antiepileptic drug in 1967 in France and has become the most widely prescribed antiepileptic drug worldwide.[43] Valproic acid has also been used for migraine prophylaxis and bipolar disorder.[44]

Society and culture

Approval status

Indications
FDA-labelled indication?[1]

TGA-labelled indication?[3]

MHRA-labelled indication?[11]
Literature support
Epilepsy Yes Yes Yes Limited.[45]
Bipolar mania Yes Yes Yes Limited.[46]
Bipolar depression No No No Moderate.[47]
Bipolar maintenance No No No Limited.[48]
Migraine prophylaxis Yes No No Limited.
Acute migraine management No No No Only negative results.[49]
Schizophrenia No No No Weak and mostly negative evidence.[50]
Agitation in dementia No No No Weak and mostly negative evidence.[51]
Fragile X syndrome Yes (orphan) No No Limited.[52]
Familial adenomatous polyposis Yes (orphan) No No Limited.
Chronic pain & fibromyalgia No No No Limited.[53]
Alcohol hallucinosis No No No One randomised double-blind placebo-controlled trial.[54]
Intractable hiccups No No No Limited, five case reports support its efficacy, however.[55]
Non-epileptic myoclonus No No No Limited, three case reports support its efficacy, however.[56]
Cluster headaches No No No Limited, two case reports support its efficacy.[57]
West syndrome No No No A prospective clinical trial supported its efficacy in treating infantile spasms.[58]
HIV infection eradication No No No Double-blind placebo-controlled trials have been negative.[59][60][61]
Myelodysplastic syndrome No No No Several clinical trials have confirmed its efficacy as a monotherapy,[62] as an adjunct to tretinoin[62] and as an adjunct to hydralazine.[63]
Acute myeloid leukaemia No No No Two clinical trials have confirmed its efficacy in this indication as both a monotherapy and as an adjunct to tretinoin.[64][65][66]
Cervical cancer No No No One clinical trial supports its use here.[67]
Malignant melanoma No No No One phase II study has seemed to discount its efficacy.[68]
Breast cancer No No No A phase II study has supported its efficacy.[69]
Impulse control disorder No No No Limited.[70][5]

Formulations

Branded products include:

Chemistry

Valproic acid, 2-propylvaleric acid, is synthesized by the alkylation of ethyl cyanoacetate with two equivalents of propyl bromide, to give dipropylcyanoacetic ester. Hydrolysis and decarboxylation of the carboethoxy group gives 2-propylpentanenitrile, which is hydrolyzed into valproic acid.[71][72][73][74]

See also

References

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Further reading

  • Chateauvieux, S. B.; Morceau, F.; Dicato, M.; Diederich, M. (2010). "Molecular and Therapeutic Potential and Toxicity of Valproic Acid" (PDF). Journal of Biomedicine and Biotechnology 2010: 1.  
  • Monti, B.; Polazzi, E.; Contestabile, A. (2009). "Biochemical, molecular and epigenetic mechanisms of valproic acid neuroprotection" (PDF). Current molecular pharmacology 2 (1): 95–109.  

External links

  • PsychEducation: Valproate/divalproex (divalproex)
  • The Comparative Toxicogenomics Database:Valproic Acid
  • Chemical Land21: Valproic Acid
  • RXList.com: Depakene (Valproic Acid) (U.S.)
  • South African Electronic Package Inserts: Convulex
  • Med Broadcast.com: Valproic Acid (Canadian)


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