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Ym-31636

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Title: Ym-31636  
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Subject: 5-HT3 receptor, RS-56812, MPPF, 9-Aminomethyl-9,10-dihydroanthracene, BRL-54443
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Ym-31636

YM-31636
Properties
Molecular formula C14H11N3S
Molar mass 253.32 g mol-1
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)

YM-31636 is a potent and selective 5-HT3 agonist.[1] Systemic administration of YM-31636 increased the number of fecal pellets in rats, and improves colonic motility. It also increases colonic secretions, but not to the point of inducing diarrhea. In addition, it did not reduce the visceral pain threshold, or increase the intensity of visceral pain.[2] These properties indicate that it could be a useful treatment for constipation.

References

  1. ^ Ito, H. (December 2000). "Pharmacological profile of YM-31636, a novel 5-HT3 receptor agonist, in vitro.". European Journal of Pharmacology 409 (2): 195–201.  
  2. ^ Kiso, T. (November 2001). "A novel 5-HT3 receptor agonist, YM-31636, increases gastrointestinal motility without increasing abdominal pain.". European Journal of Pharmacology 431 (1): 35–41.  


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