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Plos Genetics : Y Chromosome Lineage- and Village-specific Genes on Chromosomes 1P22 and 6Q27 Control Visceral Leishmaniasis in Sudan, Volume 3

By Mountain, Joanna

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Book Id: WPLBN0003924677
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos Genetics : Y Chromosome Lineage- and Village-specific Genes on Chromosomes 1P22 and 6Q27 Control Visceral Leishmaniasis in Sudan, Volume 3  
Author: Mountain, Joanna
Volume: Volume 3
Language: English
Subject: Journals, Science, Genetics
Collections: Periodicals: Journal and Magazine Collection, PLoS Genetics
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Publisher: Plos

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Mountain, J. (n.d.). Plos Genetics : Y Chromosome Lineage- and Village-specific Genes on Chromosomes 1P22 and 6Q27 Control Visceral Leishmaniasis in Sudan, Volume 3. Retrieved from http://ebook.worldlibrary.net/


Description
Description : Familial clustering and ethnic differences suggest that visceral leishmaniasis caused by Leishmania donovani is under genetic control. A recent genome scan provided evidence for a major susceptibility gene on Chromosome 22q12 in the Aringa ethnic group in Sudan. We now report a genome-wide scan using 69 families with 173 affected relatives from two villages occupied by the related Masalit ethnic group. A primary ten-centimorgan scan followed by refined mapping provided evidence for major loci at 1p22 (LOD score 5.65: nominal p¼1.72310 7: empirical p , 1310 5: kS¼ 5.1) and 6q27 (LOD score 3.74: nominal p ¼ 1.68 3 10 5: empirical p , 1 3 10 4: kS ¼ 2.3) that were Y chromosome– lineage and village-specific. Neither village supported a visceral leishmaniasis susceptibility gene on 22q12. The results suggest strong lineage-specific genes due to founder effect and consanguinity in these recently immigrant populations. These chance events in ethnically uniform African populations provide a powerful resource in the search for genes and mechanisms that regulate this complex disease.


 

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