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Plos One : Absorption of Manganese and Iron in a Mouse Model of Hemochromatosis, Volume 8

By Connor, James, R.

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Book Id: WPLBN0003943246
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos One : Absorption of Manganese and Iron in a Mouse Model of Hemochromatosis, Volume 8  
Author: Connor, James, R.
Volume: Volume 8
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Publication Date:
Publisher: Plos


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Connor, J. R. (n.d.). Plos One : Absorption of Manganese and Iron in a Mouse Model of Hemochromatosis, Volume 8. Retrieved from

Description : Hereditary hemochromatosis, an iron overload disease associated with excessive intestinal iron absorption, is commonly caused by loss of HFE gene function. Both iron and manganese absorption are regulated by iron status, but the relationships between the transport pathways of these metals and how they are affected by HFE-associated hemochromatosis remain poorly understood. Loss of HFE function is known to alter the intestinal expression of DMT1 (divalent metal transporter-1) and Fpn (ferroportin), transporters that have been implicated in absorption of both iron and manganese. Although the influence of HFE deficiency on dietary iron absorption has been characterized, potential effects on manganese metabolism have yet to be explored. To investigate the role of HFE in manganese absorption, we characterized the uptake and distribution of the metal in Hfe2/2 knockout mice after intravenous, intragastric, and intranasal administration of 54Mn. These values were compared to intravenous and intragastric administration of 59Fe. Intestinal absorption of 59Fe was increased and clearance of injected 59Fe was also increased in Hfe2/2 mice compared to controls. Hfe2/2 mice displayed greater intestinal absorption of 54Mn compared to wild-type Hfe+/+ control mice. After intravenous injection, the distribution of 59Fe to heart and liver was greater in Hfe2/2 mice but no remarkable differences were observed for 54Mn. Although olfactory absorption of 54Mn into blood was unchanged in Hfe2/2 mice, higher levels of intranasally-instilled 54Mn were associated with Hfe2/2 brain compared to controls. These results show that manganese transport and metabolism can be modified by HFE deficiency.


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