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Plos One : Insights Into the Evolution of the Csp Gene Family Through the Integration of Evolutionary Analysis and Comparative Protein Modeling, Volume 8

By Kannan, Natarajan

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Book Id: WPLBN0003950747
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos One : Insights Into the Evolution of the Csp Gene Family Through the Integration of Evolutionary Analysis and Comparative Protein Modeling, Volume 8  
Author: Kannan, Natarajan
Volume: Volume 8
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Historic
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Publisher: Plos

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Kannan, N. (n.d.). Plos One : Insights Into the Evolution of the Csp Gene Family Through the Integration of Evolutionary Analysis and Comparative Protein Modeling, Volume 8. Retrieved from http://ebook.worldlibrary.net/


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Description : Insect chemical communication and chemosensory systems rely on proteins coded by several gene families. Here, we have combined protein modeling with evolutionary analysis in order to study the evolution and structure of chemosensory proteins (CSPs) within arthropods and, more specifically, in ants by using the data available from sequenced genomes. Ants and other social insects are especially interesting model systems for the study of chemosensation, as they communicate in a highly complex social context and much of their communication relies on chemicals. Our ant protein models show how this complexity has shaped CSP evolution: the proteins are highly modifiable by their size, surface charge and binding pocket. Based on these findings, we divide ant CSPs into three groups : typical insect CSPs, an ancient 5-helical CSP and hymenopteran CSPs with a small binding pocket, and suggest that these groups likely serve different functions. The hymenopteran CSPs have duplicated repeatedly in individual ant lineages. In these CSPs, positive selection has driven surface charge changes, an observation which has possible implications for the interaction between CSPs and ligands or odorant receptors. Our phylogenetic analysis shows that within the Arthropoda the only highly conserved gene is the ancient 5-helical CSP, which is likely involved in an essential ubiquitous function rather than chemosensation. During insect evolution, the 6-helical CSPs have diverged and perform chemosensory functions among others. Our results contribute to the general knowledge of the structural differences between proteins underlying chemosensation and highlight those protein properties which have been affected by adaptive evolution.

 

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