World Library  

Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos One : Troponin and Anti-troponin Autoantibody Levels in Patients with Ventricular Noncompaction, Volume 8

By Hosoda, Toru

Click here to view

Book Id: WPLBN0003969031
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos One : Troponin and Anti-troponin Autoantibody Levels in Patients with Ventricular Noncompaction, Volume 8  
Author: Hosoda, Toru
Volume: Volume 8
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection
Publication Date:
Publisher: Plos


APA MLA Chicago

Hosoda, T. (n.d.). Plos One : Troponin and Anti-troponin Autoantibody Levels in Patients with Ventricular Noncompaction, Volume 8. Retrieved from

Description : Ventricular hypertrabeculation/noncompaction is a morphologic and functional anomaly of myocardium characterized by prominent trabeculae accompanied by deep recessus. Dilated cardiomyopathy with left ventricular failure is observed in these patients, while the cause or pathophysiologic nature of this complication is not known. Anti-troponin antibodies are formed against circulating cardiac troponins after an acute coronary event or conditions associated with chronic myocyte necrosis, such as dilated cardiomyopathy. In present study, we aimed to investigate cardiac troponins and anti troponin autoantibodies in ventricular noncompaction/hypertrabeculation patients with/without reduced ejection fraction. A total of 50 patients with ventricular noncompaction and 23 healthy volunteers were included in this study. Noncompaction/ hypertrabeculation was diagnosed with two-dimensional echocardiography using appropriate criteria. Depending on ejection fraction, patients were grouped into noncompaction with preserved EF (LVEF .50%, n = 24) and noncompaction with reduced EF (LVEF ,35%, n = 26) groups. Troponin I, troponin T, anti-troponin I IgM and anti-troponin T IgM were measured with sandwich immunoassay method using a commercially available kit. Patients with noncompaction had significantly higher troponin I (28.9869.21 ng/ml in NCNE group and 28.11610.42 ng/ml in NCLE group), troponin T (22.1766.97 pg/ml in NCNE group and 22.7867.76 pg/ml in NCLE group) and antitroponin I IgM (1.9260.43 mg/ml in NCNE group and 1.7960.36 mg/ml in NCLE group) levels compared to control group, while antitroponin T IgM and IgG were only elevated in patients with noncompaction and reduced EF (15.8166.52 mg/ml for IgM and 16.4666.25 mg/ml for IgG). Elevated cardiac troponins and anti-troponin I autoantibodies were observed in patients with noncompaction preceding the decline in systolic function and could indicate ongoing myocardial damage in these patients.


Click To View

Additional Books

  • Plos One : Berberine Reduces Fibronectin... (by )
  • Plos One : Evaluating the Feasibility an... (by )
  • Plos One : Validation of Reference Genes... (by )
  • Plos One : Influence of Nutrient Stress ... (by )
  • Plos One : Children’s and Adults’ On-lin... (by )
  • Plos One : Neutralization of Tslp Inhibi... (by )
  • Plos One : Salvage Liver Transplantation... (by )
  • Plos One : the Sox2-interactome in Brain... (by )
  • Plos One : Hyperactivity of On-type Reti... (by )
  • Plos One : the Color of Debt ; Racial Di... (by )
  • Plos One : Peroxisome Proliferator-activ... (by )
  • Plos One : Assessing Bacterial Populatio... (by )
Scroll Left
Scroll Right


Copyright © World Library Foundation. All rights reserved. eBooks from World eBook Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.