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serotonin–norepinephrine–dopamine reuptake inhibitor (X)

       
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Neuroanatomical and pharmacological correlates of the behavioral manifestations of intraventricular administration of kainic acid in the rat

By: Lanthorn, Thomas Herbert

... binding site. The sodium-dependent mechanism corresponds to a transmitter reuptake mechanism (a specific, fast-transport mechanism), while the nonspe... ...lso exists. It has an even higher affinity for glutamate than the specific reuptake mechanism, but is not sodium dependent. It is very specific for gl... ...kainate was that it appeared to be a very poor substrate for the glutamate reuptake mechanism (12,40). One report showed that an excess of kainate str... ...f 5-HTP, following pretreatment with a peripherally act- ing decarboxylase inhibitor, resulted in the occurrence of WDS. 5-HTP is the metabolic precur... ...o 10 days later. Carbidopa (25 mg/kg), a peripherally acting decarboxylase inhibitor, was injected 30 min prior to 5-HTP (100 mg/kg, i.p.). Ninety min...

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Serotonin–norepinephrine–dopamine reuptake inhibitor

Encyclopedia Article

...ptor, antihistamine, melatonin etc. A serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI), more commonly... .... A serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI), more commonly known as a triple reuptake inhibi... ... A serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI), more commonly known as a triple reuptake inhibitor (TRI)... ...or (TRI), or sometimes a TUI (DOV), is a drug that concomitantly acts as a reuptake inhibitor for the monoamine neurotransmitters, serotonin (5-HT), n... ... or sometimes a TUI (DOV), is a drug that concomitantly acts as a reuptake inhibitor for the monoamine neurotransmitters, serotonin (5-HT), norepineph... ... also display MAOI activity, although they are reversible and not 'suicide inhibitors' (alkylating agents that can form a covalent bond/s with their m... ... Preclinical and clinical research indicates that drugs inhibiting the reuptake of all (3?) of these neurotransmitters can produce a more rapid on... ...ptor, antihistamine, melatonin etc. A serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI), more commonly...

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Serotonin-norepinephrine-dopamine releasing agent

Encyclopedia Article

... Monoamine releasing agent Serotonin-norepinephrine-dopamine reuptake inhibitor Reference... ... Monoamine releasing agent Serotonin-norepinephrine-dopamine reuptake inhibitor References ... ...   Reuptake inhibitors ... ...   Reuptake inhibitors ... ... Selective norepinephrine reuptake inhibitors: Amedalin ... ... Selective norepinephrine reuptake inhibitors: Amedalin ...

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Serotonin-norepinephrine-dopamine reuptake inhibitors

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Reuptake inhibitor

Encyclopedia Article

...cker, is a drug that inhibits the plasmalemma l transporter -mediated reuptake of a neurotransmitter from the synapse into the pre-synaptic... ... and therefore an increase in neurotransmission . Various drug s utilize reuptake inhibition to exert their psychological and physiological effe... ...ects, including many antidepressants and psychostimulant s. Most known reuptake inhibitors affect the monoamine neurotransmitter s serotonin, n... ...luding many antidepressants and psychostimulant s. Most known reuptake inhibitors affect the monoamine neurotransmitter s serotonin, norepineph... ... number of pharmaceutical s and research chemical s that act as reuptake inhibitors for other neurotransmitter s such as glutamate, γ-aminobutyr... ...hanism of action Active site transporter substrates Standard reuptake inhibitors are believed to act simply as competitive substrate s that wo...

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Selective serotonin reuptake inhibitor

Encyclopedia Article

...Selective serotonin reuptake inhibitor Drug class ... ... Selective serotonin re-uptake inhibitors or serotonin-specific reuptake inhibitor[1] (SSRIs) are a class ... ... Selective serotonin re-uptake inhibitors or serotonin-specific reuptake inhibitor[1] (SSRIs) are a class of compounds typically used as an... ...he extracellular level of the neurotransmitter serotonin by inhibiting its reuptake into the presynaptic cell, increasing the level of serotonin in th... ...e non-SSRI antidepressant nefazodone, and the serotonin and norepinephrine reuptake inhibitor (SNRI) venlafaxine. The authors attributed the relations... ...I antidepressant nefazodone, and the serotonin and norepinephrine reuptake inhibitor (SNRI) venlafaxine. The authors attributed the relationship betwe...

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Monoamine oxidase inhibitor

Encyclopedia Article

...Monoamine oxidase Monoamine oxidase inhibitors (MAOIs) are chemicals which inhibit the activity of the monoamin... ...use of potentially lethal dietary and drug interactions, monoamine oxidase inhibitors have historically been reserved as a last line of treatment, use... ...hen other classes of antidepressant drugs (for example selective serotonin reuptake inhibitors and tricyclic antidepressants) have failed.[2] New rese... ... classes of antidepressant drugs (for example selective serotonin reuptake inhibitors and tricyclic antidepressants) have failed.[2] New research into... ... Serotonin, Norepinephrine, and/or Dopamine Reuptake Inhibitors: Selective Serotoni... ...uptake Inhibitors: Selective Serotonin Reuptake Inhibitors (SSRIs): Citalopram, Dapoxetine, Escitalopram, Fluoxeti...

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Reversible inhibitor of monoamine oxidase A

Encyclopedia Article

...ochondrion. From PDB 2BXS. Reversible inhibitors of monoamine oxidase A (RIMAs) are a class of drugs which select... ...sibility and selectivity, RIMAs are safer than the older monoamine oxidase inhibitors (MAOIs) like phenelzine and tranylcypromine. ... ... See also Monoamine oxidase inhibitor References ... ...   Specific reuptake inhibitors and/or receptor modulators ... ...   Reuptake inhibitors ... ... Selective norepinephrine reuptake inhibitors: Amedalin ...

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NS-2359

Encyclopedia Article

... NS-2359 (GSK-372,475) is a serotonin-norepinephrine-dopamine reuptake inhibitor. It was under development by GlaxoSmithKline (GSK) as an... ... NS-2359 (GSK-372,475) is a serotonin-norepinephrine-dopamine reuptake inhibitor. It was under development by GlaxoSmithKline (GSK) as an antidepr... ...lsen, B. (2008). "A randomized controlled trial of a novel mixed monoamine reuptake inhibitor in adults with ADHD". Behavioral and Brain Functions 4: ... ...(2008). "A randomized controlled trial of a novel mixed monoamine reuptake inhibitor in adults with ADHD". Behavioral and Brain Functions 4: 24. PMC&n... ...iuk, G.; Ratti, E. (2011). "Efficacy, safety, and tolerability of a triple reuptake inhibitor GSK372475 in the treatment of patients with major depres... ...Ratti, E. (2011). "Efficacy, safety, and tolerability of a triple reuptake inhibitor GSK372475 in the treatment of patients with major depressive diso...

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Cocaethylene

Encyclopedia Article

...cological properties make cocaethylene a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI) (also known as "triple reuptake inhibitor.") Co... ... properties make cocaethylene a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI) (also known as "triple reuptake inhibitor.") Cocaethylen...

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Nefazodone

Encyclopedia Article

...s as well, and therefore acts as a weak serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI). It has negligible affinity for the H1 recepto... ..., and therefore acts as a weak serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI). It has negligible affinity for the H1 receptor (24, 0... ..., and jaundice .http://www.drugs.com/serzone.html Unlike most serotonin reuptake inhibitor s, nefazodone has a low incidence of negative effects on... ...undice .http://www.drugs.com/serzone.html Unlike most serotonin reuptake inhibitor s, nefazodone has a low incidence of negative effects on libido ... ...tite and weight gain either. Interactions Nefazodone is a potent inhibitor of CYP3A4, an isozyme of the cytochrome P450 system, and ma...

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DOV-216,303

Encyclopedia Article

...p; Co., which is currently in clinical trials.[1] It is a so-called triple reuptake inhibitor (TRI), or serotonin-norepinephrine-dopamine reuptake inh... ...hich is currently in clinical trials.[1] It is a so-called triple reuptake inhibitor (TRI), or serotonin-norepinephrine-dopamine reuptake inhibitor (S... ... (2006). "Preclinical and Clinical Pharmacology of DOV 216,303, a "Triple" Reuptake Inhibitor". CNS Drug Reviews 12 (2): 123–134. PMID 16958986. ... ..."Preclinical and Clinical Pharmacology of DOV 216,303, a "Triple" Reuptake Inhibitor". CNS Drug Reviews 12 (2): 123–134. PMID 16958986. doi:10.11... ...   Reuptake inhibitors ... ...bsp; Reuptake inhibitors ...

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DOV-102,677

Encyclopedia Article

...nd is currently in clinical trials.[1] It is a so-called triple (re)uptake inhibitor (TUI), or serotonin-norepinephrine-dopamine reuptake inhibitor (S... ...ed triple (re)uptake inhibitor (TUI), or serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI).[1] It is the (-)-enantiomer of DOV 216,303, and... ..."Pharmacological profile of the "triple" monoamine neurotransmitter uptake inhibitor, DOV 102,677". Cellular and molecular neurobiology 26 (4–6): 857–... ...   Reuptake inhibitors ... ...bsp; Reuptake inhibitors ... ... Selective norepinephrine reuptake inhibitors: Amedalin ...

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Dopamine releasing agent

Encyclopedia Article

... Monoamine releasing agent Dopamine reuptake inhibitor References ... ... Monoamine releasing agent Dopamine reuptake inhibitor References ... ...   Reuptake inhibitors ... ...   Reuptake inhibitors ... ... DAT inhibitors ... ... Monoamine releasing agent Dopamine reuptake inhibitor References ...

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Talsupram

Encyclopedia Article

...1.48 g/mol Talsupram (Lu 5-005) is a selective norepinephrine reuptake inhibitor (NRI) which was investigated as ... ...l Talsupram (Lu 5-005) is a selective norepinephrine reuptake inhibitor (NRI) which was investigated as an antide... ...ever marketed.[1][2][3] Along with talopram, it is structurally related to the selective serotonin reuptake inhibitor (SSRI) citalopram.[4] ... ...eted.[1][2][3] Along with talopram, it is structurally related to the selective serotonin reuptake inhibitor (SSRI) citalopram.[4] ... ... H (1986). "Effects of antidepressant drugs, selective noradrenaline-or 5-hydroxytryptamine uptake inhibitors, on apomorphine-induced hypothermia in m... ...   Specific reuptake inhibitors and/or receptor modulators ...

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Talopram

Encyclopedia Article

... Talopram (Lu 3-010), also known as phthalapromine, is a selective norepinephrine reuptake inhibitor (NRI) which was researched for t... ... Talopram (Lu 3-010), also known as phthalapromine, is a selective norepinephrine reuptake inhibitor (NRI) which was researched for the manage... ... commercialized. Along with talsupram, talopram is structurally related to the selective serotonin reuptake inhibitor (SSRI) citalopram,[1] as well as... ...alized. Along with talsupram, talopram is structurally related to the selective serotonin reuptake inhibitor (SSRI) citalopram,[1] as well as to melit... ...e challenge facing him in 1971 following his recruitment was to produce a selective norepinephrine reuptake inhibitor. Like other companies at the tim... ...ge facing him in 1971 following his recruitment was to produce a selective norepinephrine reuptake inhibitor. Like other companies at the time, Lundbe...

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Norepinephrine releasing agent

Encyclopedia Article

... Releasing agent Norepinephrine reuptake inhibitor Serotonin releasing agent ... ... Releasing agent Norepinephrine reuptake inhibitor Serotonin releasing agent ... ...   Reuptake inhibitors ... ...   Reuptake inhibitors ... ... Selective norepinephrine reuptake inhibitors: Amedalin ... ... Selective norepinephrine reuptake inhibitors: Amedalin ...

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Abanoquil

Encyclopedia Article

... Adrenergic release inhibitors ... ... Adrenergic uptake inhibitor ... ... Tyrosine hydroxylase inhibitor ... ...   Reuptake inhibitors ... ... Selective norepinephrine reuptake inhibitors: Amedalin ... ... Viloxazine; Norepinephrine-dopamine reuptake inhibitors: Amineptine ...

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Xipranolol

Encyclopedia Article

... Adrenergic release inhibitors ... ... Adrenergic uptake inhibitor ... ... Tyrosine hydroxylase inhibitor ... ...   Reuptake inhibitors ... ... Selective norepinephrine reuptake inhibitors: Amedalin ... ... Viloxazine; Norepinephrine-dopamine reuptake inhibitors: Amineptine ...

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Xibenolol

Encyclopedia Article

... Adrenergic release inhibitors ... ... Adrenergic uptake inhibitor ... ... Tyrosine hydroxylase inhibitor ... ...   Reuptake inhibitors ... ... Selective norepinephrine reuptake inhibitors: Amedalin ... ... Viloxazine; Norepinephrine-dopamine reuptake inhibitors: Amineptine ...

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Adimolol

Encyclopedia Article

... Adrenergic release inhibitors ... ... Adrenergic uptake inhibitor ... ... Tyrosine hydroxylase inhibitor ... ...   Reuptake inhibitors ... ... Selective norepinephrine reuptake inhibitors: Amedalin ... ... Viloxazine; Norepinephrine-dopamine reuptake inhibitors: Amineptine ...

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